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Highly Efficient Room‐Temperature Photoresponsive DNA Tethering Azobenzene Through Backbone‐Inserted Glycerol via Ether Bond
Author(s) -
Kou Bo,
Guo Xin,
Xiao ShouJun,
Liang Xingguo
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201301134
Subject(s) - azobenzene , glycerol , tethering , ether , photoisomerization , dna , duplex (building) , chemistry , materials science , photochemistry , polymer chemistry , molecule , organic chemistry , catalysis , biochemistry , isomerization , computer science , operating system
Artificial DNA tethering a z obenzene through a backbone‐inserted glycerol via an ether bond is synthesized. The stabilization effect of the hybrid duplex with a native complementary strand of DNA for R ‐glycerol‐inserted DNA is demonstrated even when the molar ratio of azobenzene to nucleotide is 1:2. The half‐lives of tens of hours for glycerol‐tethered cis‐ azobenzene and the rapid and highly efficient trans ‐to‐ cis photoisomerization in the hybrid DNA duplex at room temperature render the manipulation of DNA nanodevices and functionalities by photoregulation in a green system possible.