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Eradication of Multi‐Drug Resistant Bacteria by a Novel Zn‐doped CuO Nanocomposite
Author(s) -
Malka Eyal,
Perelshtein Ilana,
Lipovsky Anat,
Shalom Yakov,
Naparstek Livnat,
Perkas Nina,
Patick Tal,
Lubart Rachel,
Nitzan Yeshayahu,
Banin Ehud,
Gedanken Aharon
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201301081
Subject(s) - nanocomposite , bacteria , zinc , reagent , antibacterial activity , nanoparticle , antimicrobial , staphylococcus aureus , escherichia coli , materials science , doping , nuclear chemistry , copper , suspension (topology) , chemistry , nanotechnology , organic chemistry , biology , biochemistry , metallurgy , genetics , mathematics , optoelectronics , homotopy , gene , pure mathematics
Zinc‐doped copper oxide nanoparticles are synthesized and simultaneously deposited on cotton fabric using ultrasound irradiation. The optimization of the processing conditions, the specific reagent ratio, and the precursor concentration results in the formation of uniform nanoparticles with an average size of ≈30 nm. The antibacterial activity of the Zn‐doped CuO Cu 0.88 Zn 0.12 O in a colloidal suspension or deposited on the fabric is tested against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) bacteria. A substantial enhancement of 10 000 times in the antimicrobial activity of the Zn–CuO nanocomposite compared to the pure CuO and ZnO nanoparticles (NPs) is observed after 10 min exposure to the bacteria. Similar activities are observed against multidrug‐resistant bacteria (MDR), (i.e., Methicillin‐resistant S. aureus and MDR E. coli ) further emphasizing the efficacy of this composite. Finally, the mechanism for this enhanced antibacterial activity is presented.