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Induced Adaptation of Bacillus sp. to Antimicrobial Nanosilver
Author(s) -
Gunawan Cindy,
Teoh Wey Yang,
Marquis Christopher P.,
Amal Rose
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300761
Subject(s) - cytotoxicity , antimicrobial , oxidative stress , chemistry , microbiology and biotechnology , bacteria , bacillus (shape) , biology , biochemistry , in vitro , genetics
The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver‐stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal levels of cellular ROS stimulation. An important implication of the present work is that such adaptive effects lead to the ultimate domination of nanosilver‐resistant Bacillus sp. in the microbiota, to which nanosilver cytotoxicity is continuously applied.