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Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage‐Based Optical Probe for Tumor Microenvironment Imaging
Author(s) -
Ji Tianjiao,
Zhao Ying,
Wang Jing,
Zheng Xin,
Tian Yanhua,
Zhao Yuliang,
Nie Guangjun
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300600
Subject(s) - tumor microenvironment , nanocages , fibroblast activation protein, alpha , ferritin , tumor progression , microbiology and biotechnology , chemistry , cancer research , tumor cells , biophysics , materials science , medicine , cancer , biology , biochemistry , gene , catalysis
Ferritin‐based FAP‐α‐responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP‐α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.