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Rolling Circle Amplification‐Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs
Author(s) -
Ouyang Xiangyuan,
Li Jiang,
Liu Huajie,
Zhao Bin,
Yan Juan,
Ma Yinzhou,
Xiao Shoujun,
Song Shiping,
Huang Qing,
Chao Jie,
Fan Chunhai
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300458
Subject(s) - rolling circle replication , dna , nanotechnology , drug delivery , computer science , simple (philosophy) , intracellular , computational biology , chemistry , biology , materials science , microbiology and biotechnology , biochemistry , dna polymerase , philosophy , epistemology
Several single‐stranded scaffold DNA , obtained from rolling circle amplification (RCA), are folded by different staples to form DNA nanoribbons. These DNA nanoribbons are rigid, simple to design, and cost‐effective drug carriers, which are readily internalized by mammalian cells and show enhanced immunostimulatory activity.