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Electrostatic Control of Structure in Self‐Assembled Membranes
Author(s) -
Bitton Ronit,
Chow Lesley W.,
Zha R. Helen,
Velichko Yuri S.,
Pashuck E. Thomas,
Stupp Samuel I.
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300254
Subject(s) - polyelectrolyte , membrane , chemical physics , materials science , nanostructure , phase (matter) , self assembly , molecule , diffusion , diffusion limited aggregation , static electricity , nanotechnology , chemical engineering , polymer , chemistry , organic chemistry , physics , mathematical analysis , biochemistry , fractal dimension , mathematics , engineering , quantum mechanics , fractal , composite material , thermodynamics
Self‐assembling peptide amphiphiles (PAs) can form hierarchically ordered membranes when brought in contact with aqueous polyelectrolytes of the opposite charge by rapidly creating a diffusion barrier composed of filamentous nanostructures parallel to the plane of the incipient membrane. Following this event, osmotic forces and charge complexation template nanofiber growth perpendicular to the plane of the membrane in a dynamic self‐assembly process. In this work, we show that this hierarchical structure requires massive interfacial aggregation of PA molecules, suggesting the importance of rapid diffusion barrier formation. Strong PA aggregation is induced here through the use of heparin‐binding PAs with heparin and also with polyelectrolytes of varying charge density. Small angle X‐ray scattering shows that in the case of weak PA‐polyelectrolyte interaction, membranes formed display a cubic phase ordering on the nanoscale that likely results from clusters of PA nanostructures surrounded by polyelectrolyte chains.