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A Fast Process for Imprinting Micro and Nano Patterns on Electrospun Fiber Meshes at Physiological Temperatures
Author(s) -
Nandakumar Anandkumar,
Truckenmüller Roman,
Ahmed Maqsood,
Damanik Febriyani,
Santos Diogo Reis,
Auffermann Nils,
de Boer Jan,
Habibovic Pamela,
van Blitterswijk Clemens,
Moroni Lorenzo
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300220
Subject(s) - materials science , electrospinning , nano , nanofiber , fiber , downregulation and upregulation , nanotechnology , alkaline phosphatase , cytoskeleton , biomedical engineering , biophysics , chemistry , polymer , cell , composite material , biochemistry , biology , enzyme , medicine , gene
Electrospun fiber meshes are patterned at length scales comparable to or lower than their fiber diameter. Simple nano‐ and microgrooves and closed geometric shapes are imprinted in different tones using a fast imprint process at physiological temperatures. Human mesenchymal stromal cells cultured on patterned scaffolds show differences in cellular morphology and cytoskeleton organization. Microgrooved electrospun fibers support upregulation of alkaline phosphatase and bone morphogenetic protein‐2 gene expression when cells are cultured in osteogenic medium.