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Bioinspired Patterning with Extreme Wettability Contrast on TiO 2 Nanotube Array Surface: A Versatile Platform for Biomedical Applications
Author(s) -
Lai Yuekun,
Lin Longxiang,
Pan Fei,
Huang Jianying,
Song Ran,
Huang Yongxia,
Lin Changjian,
Fuchs Harald,
Chi Lifeng
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300187
Subject(s) - nanotechnology , materials science , wetting , superhydrophilicity , microfluidics , creatures , biomolecule , drug delivery , nanotube , carbon nanotube , archaeology , natural (archaeology) , composite material , history
Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO 2 nanotube array (TNA) surface through self‐assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site‐selective cell immobilization and reversible protein absorption. Most importantly, such a high‐contrast wettability template can be used to construct various well‐defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especial for biomedical devices (e.g., high‐throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof‐of‐concept study, the surface‐enhanced Raman scattering and antibacterial performance of the fabricated 3D AgNP@TNA pattern, and the targeted drug delivery for site‐specific and high‐sensitivity cancer cell assays was investigated.