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Pericytes, Stem‐Cell‐Like Cells, but not Mesenchymal Stem Cells are Recruited to Support Microvascular Tube Stabilization
Author(s) -
Zouani Omar F.,
Lei Yifeng,
Durrieu MarieChristine
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300124
Subject(s) - mesenchymal stem cell , stem cell , microbiology and biotechnology , materials science , tube (container) , biology , composite material
An experimental model is introduced for the induction of endothelial cell (EC) tubulogenesis after 24 h of incubation on micropatterned polymer surfaces. Pericytes or mesenchymal stem cells are added separately to this system to evaluate their effect on tubular stabilization. In the absence of additional cells, the tubular structures are lost after 36 h. Addition of only pericytes, however, stabilizes the EC vasculogenic tubes.