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Regulation of an Enzyme Cascade Reaction by a DNA Machine
Author(s) -
Xin Ling,
Zhou Chao,
Yang Zhongqiang,
Liu Dongsheng
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201300019
Subject(s) - cascade , dna , enzyme , computer science , biochemical engineering , chemistry , information retrieval , artificial intelligence , biochemistry , engineering , chromatography
A strategy for the regulation of enzyme cascade reaction efficiency by a DNA machine in vitro is presented. Two cascade enzymes (GOx and HRP) are attached to the DNA machine, and the enzyme cascade reaction shows much higher efficiency when the two enzymes are brought closer by the DNA machine than when they are distant.