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Upconversion: NIR‐Triggered Release of Caged Nitric Oxide using Upconverting Nanostructured Materials (Small 24/2012)
Author(s) -
Garcia John V.,
Yang Jianping,
Shen Dengke,
Yao Chi,
Li Xiaoming,
Wang Rui,
Stucky Galen D.,
Zhao Dongyuan,
Ford Peter C.,
Zhang Fan
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290136
Subject(s) - photon upconversion , lanthanide , small molecule , nitric oxide , materials science , doping , nanocrystal , nanotechnology , excitation , near infrared spectroscopy , photochemistry , optoelectronics , chemistry , ion , biochemistry , biology , organic chemistry , neuroscience , engineering , electrical engineering
NO is a key vasodilator in mammalian cardiovascular systems and has been shown to sensitize tissue to γ‐radiation. However, photochemical NO precursors that can be activated by these NIR wavelengths are extremely limited. G. D. Stucky, D. Zhao, P. C. Ford, F. Zhang and co‐workers have addressed this issue by utilizing the known NIR to visible upconversion properties of lanthanide‐doped NaYF 4 nanocrystals. This result, described on page 3800 , is a potential game changer in multiphoton excitation‐based therapeutic delivery of NO and other small molecule bioregulators to physiological targets.