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Fluorescence Imaging: Lipid‐PEG‐Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two‐Photon Fluorescence Imaging (Small 23/2012)
Author(s) -
Geng Junlong,
Li Kai,
Ding Dan,
Zhang Xinhai,
Qin Wei,
Liu Jianzhao,
Tang Ben Zhong,
Liu Bin
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290130
Subject(s) - biocompatibility , fluorescence , peg ratio , fluorescence lifetime imaging microscopy , aggregation induced emission , nanoparticle , biophysics , absorption (acoustics) , materials science , in vivo , preclinical imaging , nanotechnology , optics , physics , finance , economics , biology , microbiology and biotechnology , metallurgy , composite material
On page 3655 , B. Liu and co‐workers develop a one‐step procedure to produce twophoton absorption nanoprobes with bright red/near‐infrared fluorescence. The nanoprobes are created by encapsulating luminogens with aggregation‐induced emission characteristics into a folate‐functionalized lipid–PEG polymer matrix. The nanoprobes, which show good biocompatibility, are internalised into cancer cells and easily detected at a depth of 400 μm, a promising result for in vitro and in vivo imaging and diagnosis.