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Neuron Adhesion: Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties (Small 21/2012)
Author(s) -
Gilles Sandra,
Winter Silke,
Michael Kristin E.,
Meffert Simone H.,
Li Pinggui,
Greben Kyrylo,
Simon Ulrich,
Offenhäusser Andreas,
Mayer Dirk
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290116
Subject(s) - neurite , colloidal gold , adhesion , nanotechnology , materials science , neuron , nanoimprint lithography , nanoparticle , cell adhesion , biophysics , chemistry , neuroscience , composite material , in vitro , fabrication , biology , biochemistry , medicine , alternative medicine , pathology
A colorized neurite of a rat cortical neuron is shown growing on a pattern of gold nanoparticles (AuNPs). The background image illustrates a larger area of AuNPs assembled in a pattern predefined by nanoimprint lithography. The AuNPs are equipped with different surface functionalities by D. Mayer and co‐workers on page 3357 , and used to investigate patterned neuron surface adhesion and neurite outgrowth. The neurites can be guided between or along the pattern using bare AuNPs or particles with positively charged ligands. Surface areas are easily switched between being cellattractive/repulsive by simple thiol chemistry.