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Drug Delivery: Hollow Copper Sulfide Nanoparticle‐Mediated Transdermal Drug Delivery (Small 20/2012)
Author(s) -
Ramadan Samy,
Guo Liangran,
Li Yajuan,
Yan Bingfang,
Lu Wei
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290110
Subject(s) - stratum corneum , materials science , transdermal , photothermal therapy , ablation , nanoparticle , laser ablation , laser , photothermal effect , drug delivery , copper , nanotechnology , chemical engineering , optics , medicine , physics , pathology , aerospace engineering , engineering , metallurgy , pharmacology
W. Lu and co‐workers apply hollow copper sulfide nanoparticles with intense photothermal conversion effects for thermal ablation of the stratum corneum through instantaneous heat conduction from an NIR laser. On page 3143 , application of a nanosecond‐pulsed laser provides short lasing periods but extremely high local temperatures, with focused thermal ablation of the stratum corneum, limiting the heat transfer to deep tissue. Thermal ablation‐induced microscale defects are confined within the lasing area. The extent of skin ablation, i.e., removal of stratum corneum, viable epidermis, or dermis, can be precisely controlled by adjusting the laser power.