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Biomimetic Mineralization: The Role of Nanoscale Architecture in Supramolecular Templating of Biomimetic Hydroxyapatite Mineralization (Small 14/2012)
Author(s) -
Newcomb Christina J.,
Bitton Ronit,
Velichko Yuri S.,
Snead Malcolm L.,
Stupp Samuel I.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290076
Subject(s) - mineralization (soil science) , nanoscopic scale , nanostructure , materials science , template , supramolecular chemistry , biomineralization , nanotechnology , biomimetics , nucleation , self assembly , chemical engineering , chemistry , crystallography , organic chemistry , crystal structure , engineering , nitrogen
When 3D peptide amphiphile assemblies with flat and cylindrical morphologies are used as templates for mineralization, the nanoscale architecture is found to play a significant role in orienting hydroxyapatite in a bone‐like fashion. Cylindrical nanostructures facilitate mineral orientation parallel to the long axis of the 1D assembly while flatter, ribbonlike architectures nucleate randomly oriented mineral. Macroscopically aligned constructs of the cylindrical nanostructures further demonstrate the ability to orient hydroxyapatite across length scales. This work by S. I. Stupp and co‐workers emphasizes the importance of template morphology.