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Biosensors: Cancer Prognostics by Direct Detection of p53‐Antibodies on Gold Surfaces by Impedance Measurements (Small 13/2012)
Author(s) -
PratsAlfonso Elisabet,
Sisquella Xavier,
Zine Nadia,
Gabriel Gemma,
Guimerà Anton,
del Campo F. Javier,
Villa Rosa,
Eisenberg Adam H.,
Mrksich Milan,
Errachid Abdelhamid,
Aguiló Jordi,
Albericio Fernando
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201290073
Subject(s) - epitope , monolayer , materials science , biosensor , antibody , prognostics , molecule , electrical impedance , nanotechnology , chemistry , computer science , biology , immunology , physics , data mining , organic chemistry , quantum mechanics
The cover image shows the detection of an antibody by its epitope immobilized through a self‐assembled monolayer on a gold surface. The detection is made possible by impedance measurements. The light dots and flashes represent the electrical conductivity through the gold surface, where two different molecules are presented: the blocking molecules to avoid non‐specific adsorption and the reactive epitopes. It is observed that the epitopes can be in different configurations to mimic the induced‐fit approach, which is carried out by the proximity of the epitope to the reactive site of the antibody. For more information, please read the Full Paper “Cancer Prognostics by Direct Detection of p53‐Antibodies on Gold Surfaces by Impedance Measurements” by E. Prats‐Alfonso, F. Albericio, and co‐workers, beginning on page 2106 . Image credit: Gemma Gabriel and Elisabet Prats‐Alfonso.