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Pattern Recognition Analysis of Proteins Using DNA‐Decorated Catalytic Gold Nanoparticles
Author(s) -
Yang Xiafeng,
Li Jiang,
Pei Hao,
Li Di,
Zhao Yun,
Gao Jimin,
Lu Jianxin,
Shi Jiye,
Fan Chunhai,
Huang Qing
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201202772
Subject(s) - colloidal gold , oligonucleotide , linear discriminant analysis , nanoparticle , computer science , nanotechnology , dna , computational biology , chemistry , biology , biochemistry , materials science , artificial intelligence
A label‐free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.