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Three Dimensional, Sheathless, and High‐Throughput Microparticle Inertial Focusing Through Geometry‐Induced Secondary Flows
Author(s) -
Chung Aram J.,
Gossett Daniel R.,
Di Carlo Dino
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201202413
Subject(s) - microparticle , throughput , inertial frame of reference , materials science , nanotechnology , geometry , mechanics , optics , physics , computer science , classical mechanics , mathematics , telecommunications , wireless
A novel inertial focusing platform creates a single‐stream microparticle train in a single‐focal plane without sheath fluids and external forces, all in a high‐throughput manner. The proposed design consists of a low‐aspect‐ratio straight channel interspersed with a series of constrictions in height arranged orthogonally, making use of inertial focusing and geometry‐induced secondary flows. Focusing efficiency as high as 99.77% is demonstrated with throughput as high as 36 000 particles s −1 for a variety of different sized particles and cells.