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IsoDGR‐Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors
Author(s) -
Curnis Flavio,
Sacchi Angelina,
Longhi Renato,
Colombo Barbara,
Gasparri Anna,
Corti Angelo
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201202310
Subject(s) - albumin , tumor necrosis factor alpha , peptide , integrin , cancer research , chemistry , biophysics , materials science , biochemistry , medicine , biology , immunology , receptor
A new cyclic peptide containing the iso DGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. Iso DGR‐tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature‐selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.