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Photosensitizer–Gold Nanorod Composite for Targeted Multimodal Therapy
Author(s) -
Wang Jian,
You Mingxu,
Zhu Guizhi,
Shukoor Mohammed Ibrahim,
Chen Zhuo,
Zhao Zilong,
Altman Meghan B.,
Yuan Quan,
Zhu Zhi,
Chen Yan,
Huang Cheng Zhi,
Tan Weihong
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201202155
Subject(s) - photosensitizer , photodynamic therapy , photothermal therapy , aptamer , singlet oxygen , materials science , biophysics , cancer research , nanotechnology , chemistry , photochemistry , medicine , microbiology and biotechnology , oxygen , biology , organic chemistry
In this work, a DNA inter‐strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer‐AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation. Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol‐Au covalent bond and then hybridized with a Ce6‐labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation. Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone.