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Evaluation of Cell Function Upon Nanovector Internalization
Author(s) -
Martinez Jonathan O.,
Parodi Alessandro,
Liu Xuewu,
Kolonin Mikhail G.,
Ferrari Mauro,
Tasciotti Ennio
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201202001
Subject(s) - nanomedicine , medicine , library science , nanotechnology , nanoparticle , computer science , materials science
In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.