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Nanoparticle Accumulation in Angiogenic Tissues: Towards Predictable Pharmacokinetics
Author(s) -
Yaehne Kristin,
Tekrony Amy,
Clancy Aisling,
Gregoriou Yiota,
Walker John,
Dean Kwin,
Nguyen Trinh,
Doiron Amber,
Rinker Kristina,
Jiang Xiao Yu,
Childs Sarah,
Cramb David
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201848
Subject(s) - nanoparticle , pharmacokinetics , materials science , drug delivery , deposition (geology) , nanotechnology , biophysics , fluorescence correlation spectroscopy , biomedical engineering , chemistry , pharmacology , medicine , organic chemistry , molecule , paleontology , sediment , biology
Nanoparticles are increasingly used in medical applications such as drug delivery, imaging, and biodiagnostics, particularly for cancer. The design of nanoparticles for tumor delivery has been largely empirical, owing to a lack of quantitative data on angiogenic tissue sequestration. Using fluorescence correlation spectroscopy, the deposition rate constants of nanoparticles into angiogenic blood vessel tissue are determined. It is shown that deposition is dependent on surface charge. Moreover, the size dependency strongly suggests that nanoparticles are taken up by a passive mechanism that depends largely on geometry. These findings imply that it is possible to tune nanoparticle pharmacokinetics simply by adjusting nanoparticle size.