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Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition
Author(s) -
Yanes Rolando E.,
Tarn Derrick,
Hwang Angela A.,
Ferris Daniel P.,
Sherman Sean P.,
Thomas Courtney R.,
Lu Jie,
Pyle April D.,
Zink Jeffrey I.,
Tamanoi Fuyuhiko
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201811
Subject(s) - exocytosis , phosphonate , mesoporous silica , drug delivery , nanoparticle , chemistry , nanotechnology , computer science , materials science , biochemistry , secretion , mesoporous material , catalysis
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P‐MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P‐MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P‐MSN exocytosis enhances the drug delivery effect of CPT‐loaded P‐MSNs by improving cell killing.