Premium
Pulsatile Drug Release from PLGA Hollow Microspheres by Controlling the Permeability of Their Walls with a Magnetic Field
Author(s) -
Chiang WeiLun,
Ke CherngJyh,
Liao ZiXian,
Chen SanYuan,
Chen FuRong,
Tsai ChunYing,
Xia Younan,
Sung HsingWen
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201743
Subject(s) - pulsatile flow , plga , materials science , permeability (electromagnetism) , microsphere , polymer , nanoparticle , diffusion , magnetic field , chemical engineering , nanotechnology , biomedical engineering , composite material , chemistry , membrane , thermodynamics , quantum mechanics , medicine , biochemistry , physics , engineering , cardiology
Pulsatile release : When a high‐frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.