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Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen‐Specific T Cell Stimulation
Author(s) -
Fadel Tarek R.,
Li Nan,
Shah Smith,
Look Michael,
Pfefferle Lisa D.,
Haller Gary L.,
Justesen Sune,
Wilson Corey J.,
Fahmy Tarek M.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201684
Subject(s) - carbon nanotube , cytotoxic t cell , covalent bond , linker , antigen , adsorption , biophysics , stimulation , materials science , chemistry , nanotechnology , in vitro , biochemistry , immunology , organic chemistry , biology , neuroscience , computer science , operating system
Antigen‐specific activation of cytotoxic T cells can be enhanced up to three‐fold more than soluble controls when using functionalized bundled carbon nanotube substrates ( b CNTs). To overcome the denaturing effects of direct adsorption on b CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non‐covalent attachment of the linker neutravidin.