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Multifunctional Au@mSiO 2 /Rhodamine B Isothiocyanate Nanocomposites: Cell Imaging, Photocontrolled Drug Release, and Photothermal Therapy for Cancer Cells
Author(s) -
Jiang Zhenlong,
Dong Biao,
Chen Boting,
Wang Jing,
Xu Lin,
Zhang Shuang,
Song Hongwei
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201558
Subject(s) - photothermal therapy , materials science , rhodamine b , drug delivery , nanotechnology , nanoparticle , nanomaterials , mesoporous silica , nanocomposite , biophysics , mesoporous material , chemistry , organic chemistry , photocatalysis , biology , catalysis
The synthesis of Au@mesoporous SiO 2 /rhodamine B isothiocyanate (Au@mSiO 2 /RBITC) composite nanoparticles (NPs) is presented and their unique biofunctional properties are studied. The structure and morphology of the NPs are characterized by X‐ray powder diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. These NPs can not only be functionalized for fluorescence imaging, but also possess well‐defined mesopore structures for drug loading and strong infrared surface plasmon absorption for light‐controlled drug release and photothermal therapy for cancer cells. In the biological experiments, one 808 nm laser is coupled to a confocal laser scanning microscopy (CLSM) system to monitor the photothermal therapy, drug release, and cell position and viability in real time by using the multichannel function of CLSM for the first time. Such novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way.