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Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells
Author(s) -
Tkach Alexey V.,
Yanamala Naveena,
Stanley Shyla,
Shurin Michael R.,
Shurin Galina V.,
Kisin Elena R.,
Murray Ashley R.,
Pareso Samantha,
Khaliullin Timur,
Kotchey Gregg P.,
Castranova Vincent,
Mathur Sanjay,
Fadeel Bengt,
Star Alexander,
Kagan Valerian E.,
Shvedova Anna A.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201546
Subject(s) - graphene , fullerene , oxide , antigen presentation , materials science , antigen , cross presentation , nanotechnology , microbiology and biotechnology , chemistry , immune system , immunology , biology , t cell , organic chemistry , metallurgy
Graphene oxide (GO) and C 60 ‐ or C 60 ‐TRIS fullerenes , internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T‐cells. While C 60 ‐fullerenes stimulate the ovalbumin‐specific MHC class I‐restricted T‐cell response, GO impairs the stimulatory potential of DCs. In contrast to C 60 ‐fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC‐based vaccines.