Premium
In Situ Monitoring Alzheimer's Disease β‐Amyloid Aggregation and Screening of Aβ Inhibitors Using a Perylene Probe
Author(s) -
Li Meng,
Zhao Chuanqi,
Yang Xinjian,
Ren Jinsong,
Xu Can,
Qu Xiaogang
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201543
Subject(s) - perylene , thioflavin , diimide , oligomer , amyloid (mycology) , cationic polymerization , chemistry , fluorescence , in situ , amyloid β , nanotechnology , combinatorial chemistry , biophysics , computational biology , alzheimer's disease , disease , medicine , materials science , molecule , biology , pathology , polymer chemistry , organic chemistry , physics , inorganic chemistry , quantum mechanics
A cationic perylene tetracarboxylic acid diimide derivative (1) is employed as a probe for in situ monitoring of Aβ aggregation and screening Aβ inhibitors. The assay is based on the fluorescence change through the aggregation of compound 1 following Aβ assembly. Importantly, this probe, compared with the well known amyloid‐staining compound thioflavin T (ThT), is more sensitive to Aβ oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer's disease.