Premium
In Situ Monitoring Alzheimer's Disease β‐Amyloid Aggregation and Screening of Aβ Inhibitors Using a Perylene Probe
Author(s) -
Li Meng,
Zhao Chuanqi,
Yang Xinjian,
Ren Jinsong,
Xu Can,
Qu Xiaogang
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201543
Subject(s) - perylene , thioflavin , diimide , oligomer , amyloid (mycology) , cationic polymerization , chemistry , fluorescence , in situ , amyloid β , nanotechnology , combinatorial chemistry , biophysics , computational biology , alzheimer's disease , disease , medicine , materials science , molecule , biology , pathology , polymer chemistry , organic chemistry , physics , inorganic chemistry , quantum mechanics
A cationic perylene tetracarboxylic acid diimide derivative (1) is employed as a probe for in situ monitoring of Aβ aggregation and screening Aβ inhibitors. The assay is based on the fluorescence change through the aggregation of compound 1 following Aβ assembly. Importantly, this probe, compared with the well known amyloid‐staining compound thioflavin T (ThT), is more sensitive to Aβ oligomer, which is highly toxic and plays a crucial role in the early stages of Alzheimer's disease.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom