Premium
Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles
Author(s) -
Liu Gang,
Gao Jinhao,
Ai Hua,
Chen Xiaoyuan
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201531
Subject(s) - iron oxide nanoparticles , iron oxide , nanotechnology , magnetic nanoparticles , nanoparticle , drug delivery , biomedicine , materials science , biocompatible material , magnetic hyperthermia , toxicity , targeted drug delivery , chemistry , bioinformatics , biomedical engineering , medicine , metallurgy , biology , organic chemistry
Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine.