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Gold Nanoparticles Downregulate Interleukin‐1β‐Induced Pro‐Inflammatory Responses
Author(s) -
Sumbayev Vadim V.,
Yasinska Inna M.,
Garcia Cesar Pascual,
Gilliland Douglas,
Lall Gurprit S.,
Gibbs Bernhard F.,
Bonsall David R.,
Varani Luca,
Rossi François,
Calzolai Luigi
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201528
Subject(s) - downregulation and upregulation , rheumatoid arthritis , in vivo , psoriasis , colloidal gold , inflammation , interleukin , medicine , immunology , interleukin 10 , extracellular , pharmacology , cancer research , immune system , nanotechnology , chemistry , cytokine , microbiology and biotechnology , materials science , nanoparticle , biology , biochemistry , gene
Interleukin 1 beta (IL‐1β)‐dependent inflammatory disorders, such as rheumatoid arthritis and psoriasis, pose a serious medical burden worldwide, where patients face a lifetime of illness and treatment. Organogold compounds have been used since the 1930s to treat rheumatic and other IL‐1β‐dependent diseases and, though their mechanisms of action are still unclear, there is evidence that gold interferes with the transmission of inflammatory signalling. Here we show for the first time that citrate‐stabilized gold nanoparticles, in a size dependent manner, specifically downregulate cellular responses induced by IL‐1β both in vitro and in vivo . Our results indicate that the anti‐inflammatory activity of gold nanoparticles is associated with an extracellular interaction with IL‐1β, thus opening potentially novel options for further therapeutic applications.