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Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma via Up‐Regulation of Myeloid‐Derived Suppressor Cells
Author(s) -
Shvedova Anna A.,
Tkach Alexey V.,
Kisin Elena R.,
Khaliullin Timur,
Stanley Shyla,
Gutkin Dmitriy W.,
Star Alexander,
Chen Yanan,
Shurin Galina V.,
Kagan Valerian E.,
Shurin Michael R.
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201470
Subject(s) - lewis lung carcinoma , immunosurveillance , cancer research , myeloid derived suppressor cell , suppressor , in vivo , tumor microenvironment , carbon nanotube , metastasis , chemistry , nanotechnology , microbiology and biotechnology , materials science , biology , medicine , tumor cells , cancer
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single‐walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid‐derived suppressor cells (MDSC), as their depletion abrogated pro‐tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.