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Dendronized Gold Nanoparticles for siRNA Delivery
Author(s) -
Kim Sung Tae,
Chompoosor Apiwat,
Yeh YiCheun,
Agasti Sarit S.,
Solfiell David J.,
Rotello Vincent M.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201141
Subject(s) - nanoparticle , nanotechnology , colloidal gold , materials science
Dendronized gold nanoparticles (AuNPs) are effective nanocarriers for small interfering RNA (siRNA) delivery. Electrostatic condension of these AuNPs with siRNA provides efficient silencing (∼50%) without cytotoxicity.