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Microfabricated Nanotopological Surfaces for Study of Adhesion‐Dependent Cell Mechanosensitivity
Author(s) -
Chen Weiqiang,
Sun Yubing,
Fu Jianping
Publication year - 2013
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201098
Subject(s) - nanotopography , extracellular matrix , mechanotransduction , microfabrication , materials science , nanotechnology , nanopillar , adhesion , cell adhesion , tissue engineering , mechanobiology , biophysics , biomedical engineering , microbiology and biotechnology , nanostructure , biology , composite material , medicine , alternative medicine , pathology , fabrication
Cells exhibit high sensitivity and diverse responses to the intrinsic nanotopography of the extracellular matrix through their nanoscale cellular sensing machinery. A simple microfabrication method for precise control and spatial patterning of the local nanoroughness on glass surfaces by using photolithography and reactive ion etching is reported. It is demonstrated that local nanoroughness as a biophysical cue could regulate a diverse array of NIH/3T3 fibroblast behaviors, including cell morphology, adhesion, proliferation, migration, and cytoskeleton contractility. The capability to control and further predict cellular responses to nanoroughness might suggest novel methods for developing biomaterials mimicking nanotopographic structures in vivo for functional tissue engineering.