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DNA–Protein Binding Force Chip
Author(s) -
Severin Philip M. D.,
Gaub Hermann E.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201201088
Subject(s) - chip , dna , nanotechnology , protein chip , atomic force microscopy , fluorescence , computer science , computational biology , biophysics , chemistry , physics , materials science , biology , bioinformatics , biochemistry , optics , telecommunications
The binding force chip (BiFo‐Chip) allows the quantification of DNA–protein interactions. It employs arrays of molecular force probes. Each molecular force probe functions comparable to a balance, which is influenced by the binding of a protein to one of the two DNA duplexes. The BiFo‐chip is easy to operate, requires only a quantitative fluorescence microscope and fulfills all essential criteria for high throughput screening.