Protein–Polymer Hybrid Nanoparticles for Drug Delivery | Zendy

Ge Jun | Zendy; Neofytou Evgenios | Zendy; Lei Jiandu | Zendy; Beygui Ramin E. | Zendy; Zare Richard N. | Zendy

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Protein–Polymer Hybrid Nanoparticles for Drug Delivery

Author(s) -

Ge Jun,

Neofytou Evgenios,

Lei Jiandu,

Beygui Ramin E.,

Zare Richard N.

Publication year - 2012

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201200889

Subject(s) - camptothecin , nanoparticle , conjugate , drug delivery , drug , amphiphile , bovine serum albumin , polymer , methacrylate , materials science , nanotechnology , drug carrier , chemistry , copolymer , organic chemistry , chromatography , pharmacology , medicine , mathematical analysis , mathematics

Amphiphilic bovine serum albumin‐poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self‐assembling. Loaded with the hydrophobic anti‐tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug.

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