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Protein–Polymer Hybrid Nanoparticles for Drug Delivery
Author(s) -
Ge Jun,
Neofytou Evgenios,
Lei Jiandu,
Beygui Ramin E.,
Zare Richard N.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200889
Subject(s) - camptothecin , nanoparticle , conjugate , drug delivery , drug , amphiphile , bovine serum albumin , polymer , methacrylate , materials science , nanotechnology , drug carrier , chemistry , copolymer , organic chemistry , chromatography , pharmacology , medicine , mathematical analysis , mathematics
Amphiphilic bovine serum albumin‐poly(methyl methacrylate) conjugate forms nanoparticles with the uniform size of ∼100 nm by self‐assembling. Loaded with the hydrophobic anti‐tumor drug camptothecin, the nanoparticle efficiently delivers drugs into cancer cells, and thus inhibits ∼79% of tumor growth in animals compared with free drug.