The Interplay of Monolayer Structure and Serum Protein Interactions on the Cellular Uptake of Gold Nanoparticles | Zendy

Zhu ZhengJiang | Zendy; Posati Tamara | Zendy; Moyano Daniel F. | Zendy; Tang Rui | Zendy; Yan Bo | Zendy; Vachet Richard W. | Zendy; Rotello Vincent M. | Zendy

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The Interplay of Monolayer Structure and Serum Protein Interactions on the Cellular Uptake of Gold Nanoparticles

Author(s) -

Zhu ZhengJiang,

Posati Tamara,

Moyano Daniel F.,

Tang Rui,

Yan Bo,

Vachet Richard W.,

Rotello Vincent M.

Publication year - 2012

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201200794

Subject(s) - monolayer , nanoparticle , colloidal gold , biophysics , chemistry , albumin , serum albumin , bovine serum albumin , nanotechnology , chemical engineering , materials science , biochemistry , biology , engineering

A critical factor for controlling serum albumin binding is surface hydrophobicity, which in turn decreases the cellular uptake of gold nanoparticles. Hydrophobic nanoparticles bind albumin more tightly, inhibiting particle uptake, with a direct correlation observed between uptake and surface hydrophobicity.

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