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The Interplay of Monolayer Structure and Serum Protein Interactions on the Cellular Uptake of Gold Nanoparticles
Author(s) -
Zhu ZhengJiang,
Posati Tamara,
Moyano Daniel F.,
Tang Rui,
Yan Bo,
Vachet Richard W.,
Rotello Vincent M.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200794
Subject(s) - monolayer , nanoparticle , colloidal gold , biophysics , chemistry , albumin , serum albumin , bovine serum albumin , nanotechnology , chemical engineering , materials science , biochemistry , biology , engineering
A critical factor for controlling serum albumin binding is surface hydrophobicity, which in turn decreases the cellular uptake of gold nanoparticles. Hydrophobic nanoparticles bind albumin more tightly, inhibiting particle uptake, with a direct correlation observed between uptake and surface hydrophobicity.