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Small Molecule–Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity towards Breast Cancer Cells
Author(s) -
Dreaden Erik C.,
Mwakwari Sandra C.,
Austin Lauren A.,
Kieffer Matthew J.,
Oyelere Adegboyega K.,
ElSayed Mostafa A.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200333
Subject(s) - atlanta , chemistry , library science , nanotechnology , materials science , medicine , computer science , metropolitan area , pathology
Gold nanoparticles are known to activate anti‐tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold–nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor‐associated macrophages towards breast cancer cells in co‐culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage‐mediated delivery applications.