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Tunable Biomolecular Interaction and Fluorescence Quenching Ability of Graphene Oxide: Application to “Turn‐on” DNA Sensing in Biological Media
Author(s) -
Hong Bong Jin,
An Zhi,
Compton Owen C.,
Nguyen SonBinh T.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200264
Subject(s) - graphene , quenching (fluorescence) , oxide , fluorescence , dna , turn (biochemistry) , materials science , nanotechnology , photochemistry , biophysics , chemistry , biochemistry , physics , optics , biology , metallurgy
As a platform for “turn‐on” DNA sensing , the level of oxidation of graphene oxide strongly affects its fluorescence quenching ability and binding interactions to single‐stranded oligodeoxyribonucleotides (ssODNs), leading to a broad range of sensitivity. Fine‐tuning the level of oxidation of graphene oxide yields a DNA‐detection platform that is highly sensitive in serum and biological media.