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Structural Effect and Mechanism of C 70 ‐Carboxyfullerenes as Efficient Sensitizers against Cancer Cells
Author(s) -
Liu Qiaoling,
Guan Mirong,
Xu Li,
Shu Chunying,
Jin Chan,
Zheng Junpeng,
Fang Xiaohong,
Yang Yongji,
Wang Chunru
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200158
Subject(s) - mechanism (biology) , cancer , materials science , cancer cell , cancer research , chemistry , nanotechnology , biophysics , medicine , biology , physics , quantum mechanics
Carboxyfullerenes with different adduct numbers and cage sizes are tested as photosensitizers for photodynamic therapy (PDT). The photodynamic efficiency of these carboxyfullerenes depends mainly on the cage size, C 60 versus C 70 , and to a lesser extent on the adduct numbers. In particular, malonic acid modified C 70 fullerenes are more efficient than their C 60 counterparts as photosensitizers, and the mechanism of cell death induced by C 70 ‐carboxyfullerene under light irradiation is investigated in detail. The results indicate that cell death occurs via necrosis accompanied by membrane blebbing, which is a unique phenomenon for photosensitizer‐induced cell death. Since C 70 ‐carboxyfullerene displays an efficient PDT property and negligible dark cytotoxicity, it is promising for use in PDT applications, especially in vascular capillary diseases usually occurring under the surface.