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Self‐Assembled Magnetic Bead Biosensor for Measuring Bacterial Growth and Antimicrobial Susceptibility Testing
Author(s) -
Kinnunen Paivo,
McNaughton Brandon H.,
Albertson Theodore,
Sinn Irene,
Mofakham Sima,
Elbez Remy,
Newton Duane W.,
Hunt Alan,
Kopelman Raoul
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200110
Subject(s) - magnetic bead , biosensor , bead , nanotechnology , bacterial growth , antibiotic resistance , magnetic nanoparticles , materials science , antimicrobial , microbiology and biotechnology , chemistry , antibiotics , bacteria , chromatography , biology , nanoparticle , composite material , genetics
Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth‐based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self‐assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6–24 hours. A 16‐well prototype is also constructed for simple and robust observation of the self‐assembled AMBR biosensors.