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Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores
Author(s) -
Na HeeKyung,
Kim MiHee,
Park Kihyun,
Ryoo SooRyoon,
Lee Kyung Eun,
Jeon Hyesung,
Ryoo Ryong,
Hyeon Changbong,
Min DalHee
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201200028
Subject(s) - gene silencing , biocompatibility , mesoporous silica , gene knockdown , nanoparticle , nanotechnology , small interfering rna , materials science , rna interference , mesoporous material , drug delivery , gene delivery , biophysics , rna , cytotoxicity , in vivo , small molecule , in vitro , chemistry , transfection , gene , biology , biochemistry , microbiology and biotechnology , metallurgy , catalysis
Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug‐delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post‐transcriptional gene silencing, so‐called RNA interference. Highly efficient, sequence‐specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.