Premium
Drug Delivery: Multiphoton Molecular Photorelease in Click‐Chemistry‐Functionalized Gold Nanoparticles (Small 23/2011)
Author(s) -
Voliani Valerio,
Ricci Fernanda,
Signore Giovanni,
Nifosì Riccardo,
Luin Stefano,
Beltram Fabio
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201190089
Subject(s) - click chemistry , surface plasmon resonance , nanotechnology , nanomedicine , conjugated system , drug delivery , colloidal gold , nanoparticle , materials science , chemistry , combinatorial chemistry , polymer , organic chemistry
The image shows an illustration of the modular nanosystem developed for the controlled photorelease of molecular payloads, induced by yellow‐green laserlight. Peptide‐coated 30‐nm gold nanospheres are covalently conjugated to molecular payloads by standard click chemistry, via a 1,2,3‐triazole‐ring linker. The photorelease of payloads is triggered in living cells by low‐power continuous‐wave 561‐nm laser light within a standard confocal microscope setup. In agreement with theoretical calculations, the process follows a nonlinear effect promoted by thestimulation of the localized surface plasmon resonance. The ability to perform controlled photocleavage of UV‐labile molecules with visible or NIR radiation opens up new, exciting possibilities for nanomedicine applications.