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Cancer Therapy: Single‐Cell‐Level Microplasma Cancer Therapy (Small 16/2011)
Author(s) -
Kim Jae Young,
Wei Yanzhang,
Li Jinhua,
Foy Paul,
Hawkins Thomas,
Ballato John,
Kim SungO
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201190059
Subject(s) - microplasma , apoptosis , tunel assay , materials science , cancer cell , cell , cancer , cancer research , nanotechnology , plasma , microbiology and biotechnology , chemistry , medicine , biochemistry , biology , physics , quantum mechanics
The image shows the apoptotic response in B16F0 tumor cells induced by a 15 μm hollow‐core optical fiber microplasma jet assay using the TUNEL assay, which detects DNA nicks–an important cell apoptotic indicator. Apoptotic tumor cells treated by the plasma device show DNA nicks, and their nuclei are dyed to a bright color by the imaging assay kit, whereas no response was found in untreated cells. A well‐defined boundary between plasma‐treated and nontreated areas can be observed. This work enables new directed cancer therapies based on a highly flexible and precise hollow, optical‐fiber‐based microplasma cancer endoscope, and it offers unique advantages to understanding plasmainduced tumor cell apoptosis.