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Controlling the Formation of DNA Origami Structures with External Signals
Author(s) -
Eskelinen AnttiPekka,
Rosilo Henna,
Kuzyk Anton,
Törmä Päivi,
Kostiainen Mauri A.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102697
Subject(s) - dna origami , dendrimer , nanotechnology , polylysine , scaffold , dna , polyelectrolyte , materials science , spermine , chemistry , polymer , nanostructure , computer science , polymer chemistry , biochemistry , database , composite material , enzyme
Degradable Newkome‐type and polylysine dendrons functionalized with spermine surface units are used to control the formation of DNA origami structures. The intact dendrons form polyelectrolyte complexes with the scaffold strands, therefore blocking the origami formation. Degradation of the dendron with an optical trigger or chemical reduction leads to the release of the DNA scaffold and efficient formation of the desired origami structure. These results provide new insights towards realizing responsive materials with DNA origami.