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Sensitive Detection of Spores Using Volume‐Amplified Magnetic Nanobeads
Author(s) -
Gómez de la Torre Teresa Zardán,
Ke Rongqin,
Mezger Anja,
Svedlindh Peter,
Strømme Maria,
Nilsson Mats
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102632
Subject(s) - spore , bacillus anthracis , detection limit , nanotechnology , chemistry , chromatography , computer science , materials science , biology , microbiology and biotechnology , genetics , bacteria
A magnetic‐nanobead‐based, substrate‐free method for the sensitive detection of spores in an immunoassay format is presented. The method is shown to detect Bacillus globigii spores, the non‐pathogenic simulant of Bacillus anthracis , with a limit‐of‐detection of 50 spores with a reaction time of 135 min. The study shows the versatility of magnetic nanobeads for detection of biological molecules other than DNA.