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Biomimetic Assembly of Proteins into Microcapsules on Oil‐in‐Water Droplets with Structural Reinforcement via Biomolecular‐Recognition‐Based Cross‐Linking of Surface Peptides
Author(s) -
Maeda Yoshiaki,
Wei Zengyan,
Matsui Hiroshi
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102571
Subject(s) - nanotechnology , materials science , biotinylation , membrane , self assembly , streptavidin , oil droplet , chemistry , biotin , biochemistry , emulsion
By mimicking the stabilization of bacterial membranes with S‐layer proteins , a novel process to fabricate highly stable protein microcapsules is introduced. In this strategy, engineered collagen peptides with site‐specific biotinylation are assembled into microcapsules on the oil‐in‐water droplets, and the resulting microcapsules are reinforced by biomolecular‐recognition‐based cross‐linking with the protein. Furthermore the microcapsules are shown to be versatile scaffolds for developing functionalized hierarchical colloidosomes for important biotechnological applications.