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Self‐Assembling Peptide‐Based Nanoparticles for siRNA Delivery in Primary Cell Lines
Author(s) -
Deshayes Sébastien,
Konate Karidia,
Rydström Anna,
Crombez Laurence,
Godefroy Cédric,
Milhiet PierreEmmanuel,
Thomas Annick,
Brasseur Robert,
Aldrian Gudrun,
Heitz Frédéric,
MuñozMorris Maria A.,
Devoisselle JeanMarie,
Divita Gilles
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102413
Subject(s) - peptide , nanoparticle , small interfering rna , amphiphile , rna interference , nanotechnology , biophysics , materials science , rna , chemistry , biochemistry , biology , copolymer , organic chemistry , polymer , gene
The secondary amphipathic peptide CADY forms stable positively charged nanoparticles with short interfering RNA (siRNA), which involves both electrostatic and hydrophobic interactions. CADY/siRNA self‐assembling nanoparticles adopt a “raspberry”‐like architecture cemented together by a matrix of free peptides. These nanoparticles are nontoxic and promote efficient delivery of siRNA in challenging primary cell lines.