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Self‐Fluorescence of Chemically Crosslinked MRI Nanoprobes to Enable Multimodal Imaging of Therapeutic Cells
Author(s) -
Kim Hyun Min,
Noh YoungWoock,
Park Hye Sun,
Cho Mi Young,
Hong Kwan Soo,
Lee Hyunseung,
Shin Da Hye,
Kang Jongeun,
Sung MoonHee,
Poo Haryoung,
Lim Yong Taik
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102361
Subject(s) - nanoprobe , in vivo , magnetic resonance imaging , glutaraldehyde , fluorescence , materials science , fluorescence lifetime imaging microscopy , nanotechnology , nuclear magnetic resonance , preclinical imaging , biomedical engineering , biophysics , chemistry , nanoparticle , medicine , radiology , biology , organic chemistry , physics , microbiology and biotechnology , quantum mechanics
Old chemistry for novel materials : Self‐fluorescent high‐relaxivity T 2 ‐weighted magnetic resonance imaging (MRI) contrast agents are produced. They are a novel type of MR/optical dual‐modality in vivo imaging nanoprobe using glutaraldehyde crosslinking chemistry, and they are used to label and monitor therapeutic cells both in vitro and in vivo.