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Gold Nanoparticles Supported on Nanoparticulate Ceria as a Powerful Agent against Intracellular Oxidative Stress
Author(s) -
Menchón Cristina,
Martín Roberto,
Apostolova Nadezda,
Victor Victor M.,
Álvaro Mercedes,
Herance José Raúl,
García Hermenegildo
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102255
Subject(s) - biocompatibility , hela , oxidative stress , reactive oxygen species , colloidal gold , antioxidant , nanoparticle , intracellular , cytosol , biophysics , viability assay , materials science , nanotechnology , apoptosis , chemistry , cell , biochemistry , biology , enzyme , metallurgy
Ceria‐supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO 2 shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO 2 against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO 2 exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO 2 carrier. Overall the result presented here shows the potential of implementing well‐established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology.