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The Role of Defects on the Assembly and Stability of DNA Nanostructures
Author(s) -
Greene Daniel G.,
Keum JungWon,
Bermudez Harry
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201102221
Subject(s) - dna origami , materials science , nanostructure , nanoscopic scale , dna , nanotechnology , melting temperature , self assembly , chemistry , composite material , biochemistry
Defects are known to underlie the mechanical properties of materials , especially so at the nanoscale. Using four compositionally identical DNA triangles, defect density is found to be inversely correlated with assembly efficiency and melting temperature. These findings are supported by a series of experiments with more complex DNA pyramids. Because they are naturally responsive to stresses, defects present an attractive opportunity as design elements for responsive DNA materials.